I found the following article about Testosterone Toxicity in MTF transsexuals to be thought provoking. It’s from 2009 so probably too recent for much formal research to have been done, and it is anecdotal so conclusions shouldn’t necessarily be reached from this alone. However, the fact that this therapist and other therapists have seen the same thing frequently does give rise to the question she asks.

People have accused me of wanting to “justify” my transsexuality. I don’t see it that way. I’m trans, I know this, and I accept this and would go forward with my transition no matter what I find medically.

But I’m also curious and I’ve been curious about science my entire life. This is no different, hence my interest in the biological causes behind being transgender, which, incidentally, actually fits into my own life rather well so far.

Enjoy the article. I found it thought provoking.